Hydroxyamine hydrochloride → HCID 18767232, compound

HRID 481168Notes

Reaction equation

HRID 481168 reaction equation
[ClH:1].[CH2:2]([CH:9]([CH2:20][N:21](C)C)[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.NO.C(C([CH2:45][N:46](C)[CH3:47])C(C1C=CC=C(OC)C=1)=O)C1C=CC=CC=1>O.C(O)C>[ClH:1].[CH2:2]([CH:9]([CH2:20][NH2:21])[CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[N:46]([CH3:47])[CH3:45])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochloride2×HCID 9948160HCID 9948160, compoundHCID 18767195HCID 18767195, compound

Product 1

HCID 18767232HCID 18767232, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The synthesis was carried out up to the third stage according to Example 1. 2-benzyl-3-dimethylamino-1-(3-methoxyphenyl)-propan-1-one hydrochloride was then converted with hydroxylamine hydrochloride to the corresponding oxime. For this purpose 5 g (0.015 mole) of 2-benzyl-3-dimethylamino-1-(3-methoxyphenyl)-propan-1-one with 2.1 g (0.03 mole) of hydroxylamine hydrochloride were dissolved in 15 ml of water and 20 ml of ethanol. The reaction time was 5 minutes and the yield of oxime was 1.7 g (33%).

Sources & evidence

ORD record
ord-1220819f815443078462846f3f57aa81
Source dataset
uspto-grants-2003_11
Patent number
US06653508B2

Reaction notes

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