Hydrochloric Acid → HCID 67680801, compound

HRID 481300Notes

Reaction equation

HRID 481300 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12]C)=[O:11])=[CH:5][CH:4]=1.[NH:14]1[CH2:19][CH2:18]N[CH2:16][CH:15]1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.[CH2:26](N(CC)CC)C.[ClH:33]>O1CCOCC1>[ClH:33].[N:14]1[CH:19]=[CH:18][CH:26]=[CH:16][C:15]=1[N:20]1[CH2:25][CH2:24][N:23]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=2)[CH2:22][CH2:21]1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 8471TriethylamineHCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetateHCID 190661411,2'-Bipiperazine

Product 1

HCID 67680801HCID 67680801, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using 2.2 g of methyl 4-bromomethylphenylacetate, 1.5 g of 1-(2-piperazinyl)piperazine, 1.9 ml of triethylamine, and 70 ml of dioxane, the reaction procedure of Example 2 was otherwise repeated and the reaction product was converted to the hydrochloride using 2N-hydrochloric acid and recrystallized from ethanol-ether to provide 1.1 g of the title compound melting at 214° C.-216° C.

Workup

  1. customthe reaction procedure of Example 2
  2. customrecrystallized from ethanol-ether

Sources & evidence

ORD record
ord-fcf65b65a63948dd9250fe992bbf0967
Source dataset
uspto-grants-1998_08
Patent number
US05789409

Reaction notes

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