Triethylamine → HCID 67680790, compound

HRID 481304Notes

Reaction equation

HRID 481304 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:16][CH:15]=1.[CH2:33](N(CC)CC)C>O1CCOCC1>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([CH:20]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:21]2[CH2:22][CH2:23][N:24]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH3:33])=[O:11])=[CH:5][CH:4]=3)[CH2:25][CH2:26]2)=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9340NorchlorcyclizineHCID 45190564-(Bromomethyl)phenylacetic acid

Product 1

HCID 67680790HCID 67680790, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using 2.4 g of 4-bromomethylphenylacetic acid, 2.9 g of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 2.8 ml of triethylamine, and 100 ml of dioxane, the reaction procedure of Example 1 was otherwise repeated and recrystallized from benzene-hexane to provide 1.8 g of methyl 4-[[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]methyl]phenylacetate melting at 113° C.-115° C.

Workup

  1. customthe reaction procedure of Example 1
  2. customrecrystallized from benzene-hexane

Sources & evidence

ORD record
ord-cb5d0562268f4f3585c07e0fc5cdeb6c
Source dataset
uspto-grants-1998_08
Patent number
US05789409

Reaction notes

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