Pyridine → HCID 19066218, compound

HRID 481362Notes

Reaction equation

HRID 481362 reaction equation
[Cl:1][C:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2C)[CH2:6][CH2:5]1)=[O:3].[F:17]C1C=CC=CC=1N1CCNCC1.ClC(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl.N1C=CC=CC=1>ClCCl>[Cl:1][C:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:17])[CH2:6][CH2:5]1)=[O:3]

Participants

6

Reactant 4

HCID 1049PyridineHCID 705291-(2-Fluorophenyl)piperazineHCID 94429TriphosgeneHCID 19066233HCID 19066233, compound

Product 1

HCID 19066218HCID 19066218, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 41A is prepared according to the procedure described for compound 15A, using the following reactants: 1-(2-fluorophenyl)piperazine (1.54 g, 8.06 mmol); triphosgene (850 mg, 2.85 mmol); pyridine (0.69 ml, 8.6 mmol); dichloromethane (60 ml).

Sources & evidence

ORD record
ord-3a4bf673753c44abb160ff17a10aff90
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

Loading…