反应详情

温度

0 °C

1-(2,3-Xylyl)piperazine hydrochloride (5 g; 25 mmol) is suspended in dichloromethane and triethylamine (7.6 ml; 54 mmol) is added. The mixture is cooled to 0° C. and bromoacetyl bromide (2.4 ml; 27 mmol) is added dropwise. The reaction is stirred for 30 minutes and then diluted in dichloromethane, washed with half-saturated sodium bicarbonate solution and dried over magnesium sulfate. The final product is purified by flash chromatography with a gradient of eluents (30/70 to 50/50; EtOAc-Pet. ether).

1. washwashed with half-saturated sodium bicarbonate solution
2. dry with materialdried over magnesium sulfate
3. customThe final product is purified by flash chromatography with a gradient of eluents (30/70 to 50/50; EtOAc-Pet. ether)