Chloroacetyl chloride → HCID 19066159, compound

HRID 481367Notes

Reaction equation

HRID 481367 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][O:7][C:8]1[C:13]([O:14][CH3:15])=[CH:12][CH:11]=[CH:10][C:9]=1[N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[Cl:1][CH2:2][C:3]([N:19]1[CH2:18][CH2:17][N:16]([C:9]2[CH:10]=[CH:11][CH:12]=[C:13]([O:14][CH3:15])[C:8]=2[O:7][CH3:6])[CH2:21][CH2:20]1)=[O:4]

Participants

5

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 11430Potassium CarbonateHCID 186690881-(2,3-Dimethoxyphenyl)piperazine

Product 1

HCID 19066159HCID 19066159, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Compound 50A is prepared according to the procedure described for compound 12, using the following reactants: chloroacetyl chloride (150 ml, 1.87 mmol); 1-(2,3-dimethoxyphenyl)piperazine (29A) (416 mg, 1.87 mmol); potassium carbonate (645 mg, 4.67 mmol); methyl ethyl ketone (20 ml).

Sources & evidence

ORD record
ord-b4de8338dec94f2fa2a54cbc171fefa7
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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