Bis(2-chloroethyl) ether → Ethyl 4-(thiophen-2-yl)oxane-4-carboxylate

HRID 481398Notes

Reaction equation

HRID 481398 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[CH3:2].Cl[CH2:13][CH2:14][O:15][CH2:16][CH2:17]Cl>>[CH2:1]([O:3][C:4]([C:5]1([C:6]2[S:7][CH:8]=[CH:9][CH:10]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:11])[CH3:2]

Participants

3

Reactant 2

HCID 8115Bis(2-chloroethyl) etherHCID 93657Ethyl 2-thienylacetate

Product 1

HCID 53937654Ethyl 4-(thiophen-2-yl)oxane-4-carboxylate

Procedure

Thiophen-2-yl-acetic acid ethyl ester (1) was dialkylated as described in Example 1, Step 1, using 1-chloro-2-(2-chloroethoxy)ethane to obtain the title compound (37).

Sources & evidence

ORD record
ord-6822c66be0f844c5a2bf027dcc29386d
Source dataset
uspto-grants-1998_08
Patent number
US05789415

Reaction notes

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