反应详情

The preparation is carried out as in Example 36 but from 2 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride, 40 ml of dimethylformamide, 1.3 g of triethylamine and 1.76 g of 2-fluorophenyl isocyanate. There is obtained 1 g of 8-[3-(2-fluorophenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a beige solid melting above 260° C. (Analysis, % calculated C: 64.00, H: 3.76, F: 5.06, N: 18.66, O: 8.52, % found C: 64.0, H: 3.5, F: 4.6, N: 18.6).