反应详情

To a solution of 4-methoxyphenylacetonitrile (5 g, 34 mmol) and NaH (2.8 g, 71 mmol) in DMSO (50 ml) was added 2-chloroethyl ether (5.3 g, 37 mmol) with cooling. The mixture was stirred at room temperature for 3 h, quenched with water, and extracted with CH2Cl2. The combined extracts were dried (Na2SO4) and concentrated in vacuo to give an oil which was purified by a column chromatography to give Compound 88 (5.3 g, 24 mmol, 71%) as a colorless oil.

1. temperaturewith cooling
2. customquenched with water
3. extractionextracted with CH2Cl2
4. dry with materialThe combined extracts were dried (Na2SO4)
5. concentrationconcentrated in vacuo
6. customto give an oil which
7. customwas purified by a column chromatography