反应详情

温度

0 °C

20 g (97.45 mmol) of 5-(2-pyridyl)-thiophene-2-carboxylic acid are dissolved in 200 ml of acetone, and the solution is treated with 15.94 ml (115 mmol) of Et3N and cooled to 0° C. A solution of 14.85 ml (115 mmol) of isobutyl chloroformate in 88 ml of acetone is slowly added dropwise with stirring to the reaction solution thus obtained. After 1 h at 0° C., a solution of 9.5 g (146 mmol) of sodium azide in 44 ml of water is added dropwise, and the mixture is stirred at 0° C. for 1 h and allowed to come to room temperature. The reaction mixture is tipped onto ice water and the precipitate is filtered off with suction and reacted further as it is.

1. customthus obtained
2. stirringthe mixture is stirred at 0° C. for 1 h
3. customto come to room temperature
4. filtrationthe precipitate is filtered off with suction
5. customreacted further as it