反应详情

温度

70 °C

3-Bromopropanol (4.0 g, 28.78 mmol), potassium phthalimide (8.0 g, 43.17 mmol) and potassium carbonate (4.0 g, 28.78 mmol) were added to 20 mL DMF. The reaction mixture was stirred at 70° C. for 4 hours, quenched with water and extracted with ethyl acetate. The organic layer was washed with water, saturated NaCl solution and evaporated in vacuo to a solid which was crystallized in ethyl acetate (3.5 g, 67%).

1. customquenched with water
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water, saturated NaCl solution
4. customevaporated in vacuo to a solid which
5. customwas crystallized in ethyl acetate (3.5 g, 67%)