反应详情

24.8 g (200 mmol) 5-methyl-resorcinol, 200 ml ether, 400 ml sodium hydrogen carbonate solution and 28.2 ml (220 mmol) benzenesulfonyl chloride were stirred for 2 d at room temperature, the organic phase was separated, the aqueous phase was extracted with ether, the combined organic phases were dried over sodium sulfate, filtered, the solvent was removed in a vacuum and 52 g (quant.) benzenesulfonic acid-3-hydroxy-5-methyl-phenyl ester was obtained. Fp 108°-110° C.

1. customthe organic phase was separated
2. extractionthe aqueous phase was extracted with ether
3. dry with materialthe combined organic phases were dried over sodium sulfate
4. filtrationfiltered
5. customthe solvent was removed in a vacuum