反应详情

The product from Example 89 (0.14 g, 0.5 mmol) was solubilized in a minimal amount of dimethylformamide and then treated with 2 mL dichloromethane, acetic anhydride (0.15 g) and triethylamine (0.15 g). After the mixture stirred at room temperature for 18 h, it was poured onto dichloromethane/water. The aqueous layer was washed with dichloromethane and the combined organic layers over sodium sulfate, filtered and evaporated to give a dark syrup. The syrup was purified by silica gel chromatography (ethyl acetate as eluant) to give the title compound (30 mg, 19% yield).

1. additionit was poured onto dichloromethane/water
2. washThe aqueous layer was washed with dichloromethane
3. filtrationthe combined organic layers over sodium sulfate, filtered
4. customevaporated
5. customto give a dark syrup
6. customThe syrup was purified by silica gel chromatography (ethyl acetate as eluant)