反应详情

The product from Example 89 (0.12 g, 0.45 mmol) was solubilized in a minimal amount of dimethylformamide and then treated with 2 mL dichloromethane, methanesulfonyl chloride (0.17 g) and triethylamine (0.15 g). After stirring at room temperature for 4 h, the mixture was washed with water, dried over sodium sulfate, filtered and evaporated. The residue was purified by silica gel chromatography (4:1 heptane:ethyl acetate as eluant) to give the title compound (30 mg, 17% yield).

1. washthe mixture was washed with water
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by silica gel chromatography (4:1 heptane:ethyl acetate as eluant)