反应详情

Concentrated hydrochloric acid (0.2 mL of 12.1M) was added to a solution of 2-methylthiazolo[4,5-c]quinolin-4-amine (0.5 g) in methanol (15 mL). Isopropanol (15 mL) was added and then the reaction mixture was heated at reflux to remove the majority of the methanol. The resulting precipitate was isolated by filtration, washed with isopropanol and dried to provide 2-methylthiazolo[4,5-c]quinolin-4-amine hydrochloride as a solid, m.p. 323-325° C. Analysis: Calculated for C11H9N3S.HCl: %C, 52.48; %H, 4.00; %N, 16.69; Found: %C, 52.46; %H, 4.08; %N, 16.52.

1. temperaturethe reaction mixture was heated
2. temperatureat reflux
3. customto remove the majority of the methanol
4. customThe resulting precipitate was isolated by filtration
5. washwashed with isopropanol
6. customdried