Hydrochloric Acid → HCID 22648270, compound

HRID 48260Notes

Reaction equation

HRID 48260 reaction equation
[ClH:1].[CH3:2][C:3]1[S:4][C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([NH2:15])[C:6]=2[N:16]=1.C(O)(C)C>CO>[ClH:1].[CH3:2][C:3]1[S:4][C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([NH2:15])[C:6]=2[N:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 9815783HCID 9815783, compound

Product 1

HCID 22648270HCID 22648270, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated hydrochloric acid (0.2 mL of 12.1M) was added to a solution of 2-methylthiazolo[4,5-c]quinolin-4-amine (0.5 g) in methanol (15 mL). Isopropanol (15 mL) was added and then the reaction mixture was heated at reflux to remove the majority of the methanol. The resulting precipitate was isolated by filtration, washed with isopropanol and dried to provide 2-methylthiazolo[4,5-c]quinolin-4-amine hydrochloride as a solid, m.p. 323-325° C. Analysis: Calculated for C11H9N3S.HCl: %C, 52.48; %H, 4.00; %N, 16.69; Found: %C, 52.46; %H, 4.08; %N, 16.52.

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux
  3. customto remove the majority of the methanol
  4. customThe resulting precipitate was isolated by filtration
  5. washwashed with isopropanol
  6. customdried

Sources & evidence

ORD record
ord-965585e4f00944e386e81b1e89d036c5
Source dataset
uspto-grants-2004_03
Patent number
US06703402B2

Reaction notes

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