反应详情

温度

0 °C

To a suspension of 195 milligrams (mg) (8.13 mM) of sodium hydride in 20 ml of anhydrous tetrahydrofuran was added, in portions, 2 g (8.13 mM) of the isopropyl 2-bromo-4-methyl-5-imidazolecarboxylate. The resulting suspension was cooled to 0° C. and 931 mg (8.13 mM) of methanesulfonyl chloride was added dropwise. The reaction mixture was stirred overnight at room temperature. The precipitated sodium chloride was removed by filtration and concentration of the filtrate in vacuo gave 2.4 g of desired product, isopropyl N-methylsulfonyl-2-bromo-4-methyl-5-imidazolecarboxylate as a yellow oil (93% yield).

1. customThe precipitated sodium chloride was removed by filtration and concentration of the filtrate in vacuo