Hydrochloric Acid → HCID 22648277, compound

HRID 48264Notes

Reaction equation

HRID 48264 reaction equation
[ClH:1].[CH2:2]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:16])[C:7]=2[N:17]=1)[CH3:3]>C(O)(C)C>[ClH:1].[CH2:2]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:16])[C:7]=2[N:17]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 99646202-Ethylthiazolo[4,5-c]quinolin-4-amine

Product 1

HCID 22648277HCID 22648277, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Concentrated hydrochloric acid (18.5 mmol) was added to a solution of 2-ethylthiazolo[4,5-c]quinolin-4-amine (4.25 g) in warm isopropanol. The reaction mixture was heated at reflux to reduce the volume and remove the water. The reaction mixture was cooled to ambient temperature. The precipitate was isolated by filtration and then dried to provide 2-ethylthiazolo[4,5-c]quinolin-4-amine hydrochloride as a solid, m.p. 268-270° C. Analysis: Calculated for C12H11N3S.HCl: %C, 54.23; %H, 4.55; %N, 15.81; Found: %C, 54.25; %H, 4.63; %N, 15.71.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux
  3. customremove the water
  4. customThe precipitate was isolated by filtration
  5. customdried

Sources & evidence

ORD record
ord-aed3a1d68c874741800041c2eaf4032c
Source dataset
uspto-grants-2004_03
Patent number
US06703402B2

Reaction notes

Loading…