Hydrogen Bromide → HCID 20242613, compound

HRID 483146Notes

Reaction equation

HRID 483146 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[O:19]C)[CH2:12][C:11]([N:21]([CH3:23])[CH3:22])=[N:10]2)=[CH:5][CH:4]=1.[BrH:24]>>[OH2:19].[BrH:24].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[OH:19])[CH2:12][C:11]([N:21]([CH3:23])[CH3:22])=[N:10]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 20242638HCID 20242638, compound

Product 1

HCID 20242613HCID 20242613, compound

Procedure

A solution of 1-(4-chlorophenyl)-3-dimethylamino-8-methoxy-1,4-dihydroisoquinoline hydrochloride (0.9 g) in 48% aqueous hydrobromic acid (100 ml) was heated at 115°-120° C. for 2.5 h. The solution was evaporated to dryness in vacuo and recrystallised from methanol-water to afford the title compound, (0.66 g), m.p. 185°-187° C.

Workup

  1. customThe solution was evaporated to dryness in vacuo
  2. customrecrystallised from methanol-water

Sources & evidence

ORD record
ord-40e1e545dd304d57beccba7cecdc4b62
Source dataset
uspto-grants-1986_03
Patent number
US04578393

Reaction notes

Loading…