Hydrogen Bromide → HCID 20242593, compound

HRID 483147Notes

Reaction equation

HRID 483147 reaction equation
O.Cl.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:19]3[C:14](=[CH:15][C:16]([O:20]C)=[CH:17][CH:18]=3)[CH2:13][C:12]([N:22]([CH3:24])[CH3:23])=[N:11]2)=[CH:6][CH:5]=1.[BrH:25]>>[BrH:25].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[C:19]3[C:14](=[CH:15][C:16]([OH:20])=[CH:17][CH:18]=3)[CH2:13][C:12]([N:22]([CH3:24])[CH3:23])=[N:11]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 20242624HCID 20242624, compound

Product 1

HCID 20242593HCID 20242593, compound

Procedure

A solution of 1-(4-chlorophenyl)-3-dimethylamino-6-methoxy-1,4-dihydroisoquinoline hydrochloride hydrate (1.5 g) in 48% aqueous hydrobromic acid (200 ml) was heated at 120° C. for 2.5 h. The solution was evaporated to dryness in in vacuo and recrystallised from ethanol-ether to give the title compound, (2.53 g),

Workup

  1. customThe solution was evaporated to dryness in in vacuo
  2. customrecrystallised from ethanol-ether

Sources & evidence

ORD record
ord-f8322ba6d73f44f69a61309fc4bd258a
Source dataset
uspto-grants-1986_03
Patent number
US04578393

Reaction notes

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