Isatin → Acetylisatin

HRID 483170Notes

Reaction equation

HRID 483170 reaction equation
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7054IsatinHCID 7918Acetic Anhydride

Product 1

HCID 11321Acetylisatin

Procedure

To 60 g of isatin was added 140 ml of acetic anhydride and the mixture was refluxed for 4 hours. The reaction mixture was cooled, and the crystals precipitated were collected by filtration, and washed with ether to obtain 58 g of N-acetylisatin.

Workup

  1. temperaturethe mixture was refluxed for 4 hours
  2. temperatureThe reaction mixture was cooled
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with ether

Sources & evidence

ORD record
ord-be4e48cba67446df94e5d35b87e7808b
Source dataset
uspto-grants-1986_03
Patent number
US04578381

Reaction notes

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