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HRID483195

反应详情

EQUATION

反应方程式

HRID 483195 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)/C=C(/C)N
HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

结构：O=Cc1cccc([N+](=O)[O-])c1F
HCID10487325

2-FLUORO-3-NITROBENZALDEHYDE

C7H4FNO3

结构：CC(=O)CC(=O)OCCN(C)Cc1ccccc1
HCID11776829

2-[Methyl(phenylmethyl)amino]ethyl 3-oxobutanoate

C14H19NO3

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1F
HCID10458542

未命名化合物

收率 50.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 330 mg of 2-fluoro-3-nitrobenzaldehyde, 252 mg of methyl 3-aminocrotonate and 506 mg of 2-(N-benzyl-N-methylamino)ethyl acetoacetate in 2 ml of 2-propanol was refluxed for 12 hours, and then the solvent was distilled off in vacuo. The residue was purified by the method of a column chromatography on silica gel to provide 492 mg of the desired compound (104).

WORKUP

后处理

  1. temperaturewas refluxed for 12 hours
  2. distillationthe solvent was distilled off in vacuo
  3. customThe residue was purified by the method of a column chromatography on silica gel