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HRID483197

反应详情

EQUATION

反应方程式

HRID 483197 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)/C=C(/C)N
HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

结构：CC(=O)CC(=O)OCCN(C)Cc1ccccc1
HCID11776829

2-[Methyl(phenylmethyl)amino]ethyl 3-oxobutanoate

C14H19NO3

结构：O=Cc1cccc(Cl)c1[N+](=O)[O-]
HCID12248972

3-CHLORO-2-NITROBENZALDEHYDE

C7H4ClNO3

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)Cc2ccccc2)C1c1cccc(Cl)c1[N+](=O)[O-]
HCID10324164

未命名化合物

收率 58.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 556 mg of 3-chloro-2-nitrobenzaldehyde, 362 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl acetoacetate in 4 ml of 2-propanol was refluxed for 6 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a method of column chromatography onon silica gel to yield 900 mg of the desired compound (108).

WORKUP

后处理

  1. temperaturewas refluxed for 6 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified by a method of column chromatography onon silica gel