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HRID483200

反应详情

EQUATION

反应方程式

HRID 483200 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1cccc(Cl)c1Cl
HCID35745

2,3-Dichlorobenzaldehyde

C7H4Cl2O

结构：COC(=O)/C=C(/C)N
HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

结构：CC(=O)CC(=O)OCC(C)(C)CN(C)Cc1ccccc1
HCID10108340

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)(C)CN(C)Cc2ccccc2)C1c1cccc(Cl)c1Cl
HCID10325127

未命名化合物

收率 47.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 175 mg of 2,3-dichlorobenzaldehyde, 126 mg of methyl 3-aminocrotonate and 320 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate in 1 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 260 mg of the desired compound (134).

WORKUP

后处理

  1. temperaturewas refluxed for 8 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified by a column chromatography on silica gel