Hydrochloric Acid → 108450-75-5

HRID 483386Notes

Reaction equation

HRID 483386 reaction equation
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:16].[CH3:17]O>>[ClH:16].[NH2:10][CH:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:15][CH:14]=1)[C:11]([O:13][CH3:17])=[O:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 137064-Nitro-3-phenyl-L-alanine

Product 1

HCID 53395976108450-75-5

Procedure

A solution of p-nitro-L-phenylalanine (12.6 g) and c.HCl (7.5 g) in methanol (150 ml) was refluxed for 1.5 hours and the solvent then evaporated in vacuo. The residue was triturated with ether and recrystallised from SVM to give the desired product as a off-white solid, [α]25 +15.3° (c=0.55, MeOH).

Workup

  1. customthe solvent then evaporated in vacuo
  2. customThe residue was triturated with ether
  3. customrecrystallised from SVM

Sources & evidence

ORD record
ord-71a8162ecd834347b161bb44eb91ad7d
Source dataset
uspto-grants-1993_07
Patent number
US05225431

Reaction notes

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