Hydrochloric Acid → HCID 19752585, compound

HRID 483388Notes

Reaction equation

HRID 483388 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[N:10]([CH3:23])[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:25]>C(O)C.O.[Pd]>[ClH:25].[NH2:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][CH:11]2[CH2:12][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9](=[O:24])[N:10]2[CH3:23])=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57039846HCID 57039846, compound

Product 1

HCID 19752585HCID 19752585, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 19096565Water ethanolSolvent

Procedure

A mixture of the product from step (a) (2.2 g), 10% Pd/C (400 mg) and 2N aqu. HCl (4.3 ml) in ethanol/water (27.8 ml, 3:5 v/v) was hydrogenated at room temperature and atmospheric pressure for 24 hours (uptake ca 200 ml). The mixture was filtered through celite, the residue washed with hot water and the filtrate evaporated in vacuo to give the desired product as a white solid (2.1 g).

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe mixture was filtered through celite
  3. washthe residue washed with hot water
  4. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-4e50411447064047abb1e2a6cb097459
Source dataset
uspto-grants-1993_07
Patent number
US05225431

Reaction notes

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