反应详情

Norpethidine (15.63 g, 67 mmol), 4-ethoxybutylchloride (10.67 g, 70 mmol), Na2CO3 (7.77 g, 73 mmol), KI (0.6 g) and acetonitrile (150 ml) were heated under reflux and stirring for 72 h. The mixture was filtered and the solvent removed. The residue was dissolved in diethyl ether, and the solution washed with water and dried (MgSO4). Destillation yielded 17.9 g of base boiling at 160°-163° C./0.05 mm Hg. B.p. acc. to J. Chem. Soc. 3062 (1958) 180° C./1 mm Hg. Hydrochloride m.p. 143°-145° C.

1. temperatureunder reflux
2. filtrationThe mixture was filtered
3. customthe solvent removed
4. dissolutionThe residue was dissolved in diethyl ether
5. washthe solution washed with water
6. dry with materialdried (MgSO4)
7. customDestillation yielded 17.9 g of base boiling at 160°-163° C./0.05 mm Hg
8. custom3062 (1958) 180° C./1 mm Hg