Hydrochloric Acid → HCID 18957817, compound

HRID 483799Notes

Reaction equation

HRID 483799 reaction equation
Cl.[CH2:2]([N:8]1[CH2:13][CH2:12][C:11]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([C:14]([O:16]CC)=O)[CH2:10][CH2:9]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:25]([NH2:27])[CH3:26].Cl>>[CH2:25]([NH:27][C:14]([C:11]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:10][CH2:9][N:8]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH2:13][CH2:12]1)=[O:16])[CH3:26]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6341EthylamineHCID 18957814HCID 18957814, compound

Product 1

HCID 18957817HCID 18957817, compound

Procedure

This compound was prepared as above form ethyl 1-hexyl-4-phenyl-4-piperidinecarboxylate hydrochloride (3.54 g, 10 mmol) and ethylamine (2.25 g, 50 mmol). Reaction time 2 days. The crude product (1.0 g) was recrystallized from disopropyl ether, yielding 0.81 g with m.p. 92°-94° C. Hydrochloride m.p. 221°-223° C. (form 2% aqueous acetone).

Workup

  1. customReaction time 2 days
  2. customThe crude product (1.0 g) was recrystallized from disopropyl ether
  3. customyielding 0.81 g with m.p. 92°-94° C

Sources & evidence

ORD record
ord-603fa34b43724b64a28133dd063e398a
Source dataset
uspto-grants-1993_07
Patent number
US05227389

Reaction notes

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