Hydrochloric Acid → HCID 67856104, compound

HRID 483808Notes

Reaction equation

HRID 483808 reaction equation
[CH3:1][O:2][C:3]([CH2:5][N:6]([NH:16][C@H:17]([C:21]([NH:23]C(OC(C)(C)C)=O)=[O:22])[CH2:18][S:19][CH3:20])[C:7]1[CH:15]=[CH:14][C:10]2[O:11][CH2:12][O:13][C:9]=2[CH:8]=1)=[O:4].[ClH:31]>C(OCC)(=O)C>[ClH:31].[CH3:1][O:2][C:3]([CH2:5][N:6]([NH:16][C@H:17]([C:21]([NH2:23])=[O:22])[CH2:18][S:19][CH3:20])[C:7]1[CH:15]=[CH:14][C:10]2[O:11][CH2:12][O:13][C:9]=2[CH:8]=1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67856172HCID 67856172, compound

Product 1

HCID 67856104HCID 67856104, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

After 4.67 g (11 mmol) of (N-methoxycarbonylmethyl-1,3-benzodioxol-5-ylamino)-N-t-butoxycarbonyl-S-methyl-L-cysteinamide were dissolved in 100 ml of ethyl acetate, an excess of hydrochloric acid was ebulated. A precipitate so formed was collected by filtration, washed with ether and then dried under reduced pressure, whereby 3.3 g of (N-methoxycarbonylmethyl-1,3-benzodioxol-5-ylamino)-S-methyl-L-cysteinamide hydrochloride were obtained (yield: 83%).

Workup

  1. customA precipitate so formed
  2. filtrationwas collected by filtration
  3. washwashed with ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-722689bf2fd441528b56a7dcce029294
Source dataset
uspto-grants-1993_07
Patent number
US05227398

Reaction notes

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