1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 22743229, compound

HRID 48384Notes

Reaction equation

HRID 48384 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:11])[CH2:9][NH2:10])[CH:5]=[CH:6][CH:7]=1.[CH:12]([S:15](Cl)(=[O:17])=[O:16])([CH3:14])[CH3:13].C1CCN2C(=NCCC2)CC1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:11])[CH2:9][NH:10][S:15]([CH:12]([CH3:14])[CH3:13])(=[O:17])=[O:16])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 824082-Propanesulfonyl chlorideHCID 227432612-(3-Bromophenyl)propan-1-amine

Product 1

HCID 22743229HCID 22743229, compoundYield 31%

Procedure

2-(3-Bromophenyl)propylamine (9.7 g, 45.3 mmol) was combined with isopropylsulfonyl chloride (6.1 mL, 54.4 mmol), and DBU (10.2 mL, 68 mmol) in a manner analogous to the procedure described in example 2 to provide the final title compound, [2-(3-bromophenyl)propyl][(methylethyl)sulfonyl]amine, (4.5 g, 31%) as a white crystalline solid. Electron spray M.S. 320 (M*−H).

Sources & evidence

ORD record
ord-8c38b7ef7c134524a82920fd624fb789
Source dataset
uspto-grants-2004_03
Patent number
US06703425B2

Reaction notes

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