Sodium Iodide → 3-[4-[1-(3-Methoxyphenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride

HRID 484126Notes

Reaction equation

HRID 484126 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10](=[O:11])[CH2:9][S:8][CH2:7]1.[ClH:12].Cl.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[ClH:12].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([N:22]2[CH2:27][CH2:26][N:25]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:10](=[O:11])[CH2:9][S:8][CH2:7]3)[CH2:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 814291-(3-Methoxyphenyl)piperazine dihydrochlorideHCID 108475053-(4-Bromobutyl)-4-thiazolidinone

Product 1

HCID 148561343-[4-[1-(3-Methoxyphenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 3-(4-bromobutyl)-4-thiazolidinone (3.0 g) and 1-(3-methoxyphenyl)piperazine dihydrochloride (3.34 g) in 100 ml of anhydrous CH3CN were added K2CO3 (8.7 g) and NaI (200 mg). The mixture was heated to 80° with stirring under N2.

Workup

  1. temperatureThe mixture was heated to 80°

Sources & evidence

ORD record
ord-b34c3c678a544c8d8261c9a5190647fc
Source dataset
uspto-grants-1993_07
Patent number
US05229388

Reaction notes

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