Water → 3-[4-[1-(4-Fluorophenyl)-4-piperazinyl]butyl]-1,4-dioxothiazolidine

HRID 484131Notes

Reaction equation

HRID 484131 reaction equation
O.[O:2]=[S:3]1(=O)[C:7](C)(C)[C:6](=[O:10])[N:5]([CH2:11][CH2:12][CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[CH:4]1C>C1COCC1>[F:27][C:24]1[CH:23]=[CH:22][C:21]([N:18]2[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][CH2:12][CH2:11][N:5]3[C:6](=[O:10])[CH2:7][S:3](=[O:2])[CH2:4]3)[CH2:16][CH2:17]2)=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 962WaterHCID 189803961,1-Dioxo-3-(4-(1-(4-fluorophenyl)-piperazin-4-yl)butyl)-2,5,5-trimethyl-4-thiazolidinone

Product 1

HCID 148561683-[4-[1-(4-Fluorophenyl)-4-piperazinyl]butyl]-1,4-dioxothiazolidineYield 52.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A second run using NaIO4 (1.41 g), H2O (13 ml), 1 (2.02 g) and THF (20 ml) was conducted in a similar manner yielding 0.910 g of product.

Sources & evidence

ORD record
ord-d44c54b9aa61448fad84e54ec069032e
Source dataset
uspto-grants-1993_07
Patent number
US05229388

Reaction notes

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