反应详情

温度

100 °C

7.85 g (38.4 mmol) of 4-hydroxyphenyl cyclohexyl ketone are heated under reflux for 2 h after addition of 12 g (86.8 mmol) of potassium carbonate and 200 ml of dimethylformamide. 8.54 g (39.9 mmol) of 2-chloromethylquinoline hydrochloride are then added at room temperature. The reaction mixture is stirred at 100° C. for 7 h and subsequently concentrated in vacuo. The residue is taken up in dichloromethane, and the organic phase is washed with water, dried over sodium sulphate and concentrated in vacuo. A column chromatographic purification on silica gel using dichloromethane/methanol (50:1) follows.

1. temperatureunder reflux for 2 h
2. concentrationsubsequently concentrated in vacuo
3. washthe organic phase is washed with water
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated in vacuo
6. customA column chromatographic purification on silica gel