Hydrochloric Acid → N-[4-(2-Methyl-1H-imidazol-1-yl)phenyl]-4-(tetradecyloxy)benzeneacetamide monohydrochloride

HRID 484607Notes

Reaction equation

HRID 484607 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:37])[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[CH:18][CH:17]=3)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.[ClH:38]>O1CCCC1.CCOCC>[ClH:38].[CH3:1][C:2]1[N:3]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:37])[CH2:15][C:16]3[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[CH:20][CH:21]=3)=[CH:11][CH:12]=2)[CH:4]=[CH:5][N:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15030162N-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-4-(tetradecyloxy)benzeneacetamide

Product 1

HCID 19925398N-[4-(2-Methyl-1H-imidazol-1-yl)phenyl]-4-(tetradecyloxy)benzeneacetamide monohydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 500 mg of N-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-4-(tetradecyloxy)benzeneacetamide in 7 ml of tetrahydrofuran and 70 ml of ether is saturated with hydrogen chloride. The solid is collected by centrifugation, washed three times with ether and vacuum dried to give 0.5 g of the desired product as a white solid, m.p. 207°-211° C.

Workup

  1. customThe solid is collected by centrifugation
  2. washwashed three times with ether and vacuum
  3. customdried

Sources & evidence

ORD record
ord-9ff44398050449f095fcbeeef09977af
Source dataset
uspto-grants-1993_07
Patent number
US05231182

Reaction notes

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