p-Toluenesulfonic acid → HCID 20272013, compound

HRID 484699Notes

Reaction equation

HRID 484699 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:24]=[C:23]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=3)[C:22]([C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=3)=[CH:21][CH:20]=2)=[CH:15][CH:14]=1>C(OCC)C>[CH3:11][C:1]1[CH:2]=[CH:3][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:5][CH:6]=1.[F:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[N:24]=[C:23]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=3)[C:22]([C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=3)=[CH:21][CH:20]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 20272009HCID 20272009, compound

Product 1

HCID 20272013HCID 20272013, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 0.49 g. of p-toluenesulfonic acid in 50 ml. of diethyl ether was added to a solution of 1.00 g. of 6-(4-fluorophenyl)-2,3-bis(4-methoxyphenyl)pyridine in 50 ml. of diethyl ether. The resulting light yellow precipitate was recovered by filtration affording 1.29 g. of the desired title product, m.p. about 166°-167° C.

Workup

  1. filtrationThe resulting light yellow precipitate was recovered by filtration
  2. customaffording 1.29 g

Sources & evidence

ORD record
ord-949c480f9bd44237bad25e2476d158a6
Source dataset
uspto-grants-1985_08
Patent number
US04533666

Reaction notes

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