Methyl iodide → HCID 13520146, compound

HRID 484805Notes

Reaction equation

HRID 484805 reaction equation
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])[NH2:6].[C:21](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[CH3:21][NH:6][C:5]1[CH:7]=[CH:8][C:9]([N:10]2[C:11](=[O:20])[C:12]3=[CH:19][CH:18]=[CH:17][CH:16]=[C:13]3[C:14]2=[O:15])=[C:3]([CH3:2])[CH:4]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 131714297HCID 131714297, compound

Product 1

HCID 13520146HCID 13520146, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To a mixture of the product aniline of Example 31 (15 g) and 18 g of anhydrous potassium carbonate suspended in 400 ml of dimethylformamide was added 11 g of methyl iodide in 30 ml of dimethylformamide. After 16 hours the mixture was concentrated to an oily residue which solidified upon trituration with water. The crude solid was purified by chromatography as in Example 34 to give the title compound. Samples prepared by the methods of Examples 34 and 36 were identical.

Workup

  1. concentrationAfter 16 hours the mixture was concentrated to an oily residue which
  2. customThe crude solid was purified by chromatography as in Example 34

Sources & evidence

ORD record
ord-47a631a72f384370b65d1561c95a3b8e
Source dataset
uspto-grants-1985_08
Patent number
US04533739

Reaction notes

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