Hydrochloric Acid → 1-(3-Diethylaminopropyl)-3-amino-4-chloroindazole dihydrochloride

HRID 484840Notes

Reaction equation

HRID 484840 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11]([Cl:16])[CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:17])=[N:8]1)[CH3:2].[ClH:20].C(OCC)C>C(O)C>[ClH:16].[ClH:20].[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11]([Cl:16])[CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:17])=[N:8]1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132293251-(3-Diethylaminopropyl)-3-amino-4-chloroindazole

Product 1

HCID 201359051-(3-Diethylaminopropyl)-3-amino-4-chloroindazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 15 ml of absolute ethyl alcohol was dissolved 1.50 g of 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-b3b956e2409643ceb8689a79a9e7c5ae
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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