反应详情

Benzyl chloroformate (8.5 g.) is added to a stirred mixture of 3-(phenylmethyl)piperazinone (XXIX, Example 62, 6.8 g.), chloroform (75 ml.), and saturated sodium bicarbonate solution (20 ml.). After 30 minutes the chloroform phase is separated, washed twice with water, and concentrated. The residual oil is crystallized from ethyl acetate-SSB and then ethyl acetate again to give the title compound, m.p. 125°-127.5°.

1. customAfter 30 minutes the chloroform phase is separated
2. washwashed twice with water
3. concentrationconcentrated
4. customThe residual oil is crystallized from ethyl acetate-SSB