Phosphorus oxychloride → Ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetate

HRID 485007Notes

Reaction equation

HRID 485007 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][CH:9]([C:16](=[O:21])[CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C)C=O>[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[O:21][C:16]([CH2:17][CH:18]([CH3:20])[CH3:19])=[C:9]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 20271337HCID 20271337, compound

Product 1

HCID 13488810Ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetateYield 75.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.5 g of ethyl 3-(4-fluorobenzoylamino)-3-isovalerylpropionate, 20 ml of dimethylformamide and 4.1 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 2.5 g of ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetate are thereby obtained. Yield: 75.5%.

Sources & evidence

ORD record
ord-9f47ac5ce1ff4bc1b463cffb3f300a9f
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

Loading…