Phosphorus oxychloride → HCID 13488811, compound

HRID 485008Notes

Reaction equation

HRID 485008 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH:9]([C:16](=[O:18])[CH3:17])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C)C=O>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]2[O:18][C:16]([CH3:17])=[C:9]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13488804Ethyl 3-(4-chlorobenzamido)-4-oxopentanoate

Product 1

HCID 13488811HCID 13488811, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.98 g of ethyl 3-(4-chlorobenzoylamino)-3-acetylpropionate, 15 ml of dimethylformamide and 1.8 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 1.98 g of ethyl 2-[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]acetate are thereby obtained. Yield: 70.9%.

Sources & evidence

ORD record
ord-35f9c8b1c25f44d98c95aa7d127dd05f
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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