Benzoyl chloride → N-(3-Methyl-2-oxobutyl)benzamide

HRID 485019Notes

Reaction equation

HRID 485019 reaction equation
Cl.[C:2]([CH2:7][NH2:8])(=[O:6])[CH:3]([CH3:5])[CH3:4].C(=O)(O)[O-].[Na+].[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:14]([NH:8][CH2:7][C:2](=[O:6])[CH:3]([CH3:5])[CH3:4])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 516892Sodium BicarbonateHCID 134017361-Amino-3-methylbutan-2-one hydrochloride

Product 1

HCID 13490305N-(3-Methyl-2-oxobutyl)benzamideYield 90.5%

Procedure

4.5 g of isobutyrylmethylamine hydrochloride, 11 g of sodium bicarbonate and 4.81 g of benzoyl chloride are treated in the same manner as described in Preparation 1-(4). 6.07 g of N-benzoylisobutyrylmethylamine are thereby obtained. Yield: 90.5%.

Workup

  1. customas described in Preparation 1-(4)

Sources & evidence

ORD record
ord-46595f3b9bd7476498cdb89e27b7c56d
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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