4-Fluorobenzoyl chloride → N-(4-fluorobenzoyl)isobutyrylmethylamine

HRID 485021Notes

Reaction equation

HRID 485021 reaction equation
Cl.[C:2]([CH2:7][NH2:8])(=[O:6])[CH:3]([CH3:5])[CH3:4].C(=O)(O)[O-].[Na+].[F:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:8][CH2:7][C:2](=[O:6])[CH:3]([CH3:5])[CH3:4])=[O:20])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 678794-Fluorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 134017361-Amino-3-methylbutan-2-one hydrochloride

Product 1

HCID 13490306N-(4-fluorobenzoyl)isobutyrylmethylamineYield 89.4%

Procedure

4.0 g of isobutyrylmethylamine hydrochloride, 6.1 g of sodium bicarbonate and 5.1 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(4). 5.8 g of N-(4-fluorobenzoyl)isobutyrylmethylamine are thereby obtained. Yield: 89.2%.

Workup

  1. customas described in Preparation 1-(4)

Sources & evidence

ORD record
ord-2b415b9ba8c64dc1b48f47c9afb60913
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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