4-Chlorobenzoyl chloride → 4-Chloro-N-(4-methyl-2-oxopentyl)benzamide

HRID 485023Notes

Reaction equation

HRID 485023 reaction equation
Cl.[C:2]([CH2:8][NH2:9])(=[O:7])[CH2:3][CH:4]([CH3:6])[CH3:5].C(=O)(O)[O-].[Na+].[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH:9][CH2:8][C:2](=[O:7])[CH2:3][CH:4]([CH3:6])[CH3:5])=[O:21])=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 85014-Chlorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 137017551-Amino-4-methylpentan-2-one hydrochloride

Product 1

HCID 134903074-Chloro-N-(4-methyl-2-oxopentyl)benzamideYield 97.5%

Procedure

3.8 g of isovalerylmethylamine hydrochloride, 5.04 g of sodium bicarbonate and 4.9 g of 4-chlorobenzoyl chloride are treated in the same manner as described in Preparation 1-(4). 6.2 g of N-(4-chlorobenzoyl)isovalerylmethylamine are thereby obtained. Yield: 98.0.

Workup

  1. customas described in Preparation 1-(4)

Sources & evidence

ORD record
ord-7ca0d74dc2174541b0f38c4a8420904b
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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