Potassium Carbonate → HCID 13343575, compound

HRID 485236Notes

Reaction equation

HRID 485236 reaction equation
[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[C:9]([OH:11])[CH:10]=1.Cl[CH2:24][P:25]([CH3:28])(=[O:27])[OH:26].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:24][P:25]([CH2:28][O:11][C:9]1[CH:10]=[C:5]([O:4][C:3]2[CH:15]=[CH:16][C:17]([C:19]([F:21])([F:20])[F:22])=[CH:18][C:2]=2[Cl:1])[CH:6]=[CH:7][C:8]=1[N+:12]([O-:14])=[O:13])(=[O:26])[OH:27]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1620645-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenolHCID 13343574HCID 13343574, compound

Product 1

HCID 13343575HCID 13343575, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrophenol (2.5 mmol), chloromethyl methylphosphinic acid (3.8 mmol), potassium carbonate (5.0 mmol) and dimethylformamide (5 ml) is heated to 120° for 2 hours. The reaction mixture is then acidified and extracted with ether. The combined ether extracts are washed with water, dried and evaporated to dryness to yield P-methyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxymethylphosphinic acid.

Workup

  1. temperatureis heated to 120° for 2 hours
  2. extractionextracted with ether
  3. washThe combined ether extracts are washed with water
  4. customdried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-0c8609bce8584d00ad86751cb08adde0
Source dataset
uspto-grants-1985_08
Patent number
US04536355

Reaction notes

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