Hydrochloric Acid → HCID 20270154, compound

HRID 485305Notes

Reaction equation

HRID 485305 reaction equation
[ClH:1].[C:2]1([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.C(OCC)C>CO>[ClH:1].[C:2]1([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13520555HCID 13520555, compound

Product 1

HCID 20270154HCID 20270154, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A twofold stoichiometric excess of 3% hydrogen chloride in methanol is added to a solution of 1.0 g. of 1-(1-naphthyloxy)-8-(N,N-dimethylamino)octane in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized to give 1-(1-naphthyloxy)-8-(N,N-dimethylamino)octane hydrochloride, m.p. 142°-143.5° C.

Workup

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-a518a9935aca4316a92a60e687f8a4ba
Source dataset
uspto-grants-1985_08
Patent number
US04536503

Reaction notes

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