Thionyl Chloride → HCID 13520516, compound

HRID 485318Notes

Reaction equation

HRID 485318 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[NH:14][C:15]2[C:20]([C:21]=1[CH2:22][CH2:23][C:24]([OH:26])=O)=[CH:19][CH:18]=[CH:17][CH:16]=2.S(Cl)([Cl:29])=O>O1CCCC1>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[NH:14][C:15]2[C:20]([C:21]=1[CH2:22][CH2:23][C:24]([Cl:29])=[O:26])=[CH:19][CH:18]=[CH:17][CH:16]=2

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 135205153-[2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-1H-indol-3-yl]propanoic acid

Product 1

HCID 13520516HCID 13520516, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 5.1 g (0.0147 mole) of 2-(5-methyl-3-phenyl-4-isoxazolyl)-3-indole propionic acid and 7.0 g (0.059 mole) of thionyl chloride in 200 ml tetrahydrofuran is stirred for 18 hours at room temperature. The solvent is then removed in vacuo to give 2-(5-methyl-3-phenyl-4-isoxazolyl)-3-indole propionyl chloride.

Workup

  1. customThe solvent is then removed in vacuo

Sources & evidence

ORD record
ord-b84cd811f27d431a80e7eb7a49a081e8
Source dataset
uspto-grants-1985_08
Patent number
US04536499

Reaction notes

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