反应详情

1 G. 8-hydroxydibenzo[b,f]thiepin-3-carboxylic acid is stirred in 50 cc. dimethylformamide with 1.5 g. potassium carbonate and 3 cc. methyl iodide. 100 CC. water is added to the reaction mixture, heated for three hours and then extracted with ethyl acetate, and the aqueous layer acidified. The precipitated solid is filtered, washed with water and a small volume of cold methanol, and dried. Yield of the desired material 700 mg.

1. temperatureheated for three hours
2. extractionextracted with ethyl acetate
3. filtrationThe precipitated solid is filtered
4. washwashed with water
5. dry with materiala small volume of cold methanol, and dried