反应详情

9-Hydroxy-9H-fluorene-9-carboxylic acid (Aldrich Chemical, Inc.) (20.0 g, 88.4 mmol) was added to 100 mL methanol saturated with hydrogen chloride and mixture was stirred at reflux for 4 h. The crystalline material obtained on cooling was collected by filtration and washed with cold 1:1 ethyl acetate/hexane to provide after drying (1), 15.8 g (74%).

1. temperatureat reflux for 4 h
2. customThe crystalline material obtained
3. temperatureon cooling
4. filtrationwas collected by filtration
5. washwashed with cold 1:1 ethyl acetate/hexane
6. customto provide
7. dry with materialafter drying (1), 15.8 g (74%)