反应详情

温度

80 °C

In a 500 ml four-necked flask were charged 12.2 g (43.7 mmol) of 5-hydroxy-2-(4-benzyloxyphenyl)pyrimidine, 24 g (65.5 mmol) of (R)-2-tetrahydropyranyloxyheptyl tosylate, 12 g of potassium carbonate, and 183 ml of DMF, and the mixture was stirred at 80° C. for 5 hours. After cooling, the reaction mixture was poured into 500 ml of ice-water and extracted with ethyl acetate. The extract was washed with water, and the solvent was removed by distillation under reduced pressure to obtain 28.6 g of a crude product, which was purified by silica gel column chromatography to obtain 25.3 g of the titled compound.

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. customthe solvent was removed by distillation under reduced pressure
5. customto obtain 28.6 g of a crude product, which
6. customwas purified by silica gel column chromatography