Oxalic Acid → HCID 178520428, compound

HRID 486051Notes

Reaction equation

HRID 486051 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[N:18]=[CH:19][NH:20][CH:21]=3)[CH2:13][CH2:12]2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:22]([OH:27])(=[O:26])[C:23]([OH:25])=[O:24].C(OCC)C>C(O)(C)C>[C:22]([OH:27])(=[O:26])[C:23]([OH:25])=[O:24].[C:1]1([CH2:7][CH2:8][C:9]([N:11]2[CH2:12][CH2:13][CH:14]([C:17]3[N:18]=[CH:19][NH:20][CH:21]=3)[CH2:15][CH2:16]2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 971Oxalic AcidHCID 3283Diethyl EtherHCID 178520427HCID 178520427, compound

Product 1

HCID 178520428HCID 178520428, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.5 (0.0017 mol) of 1-(3-phenylpropionyl)-4-(1H-imidazol-4-yl)piperidine and 1.2 equivalents of oxalic acid dissolved in 35 ml of isopropanol are brought to reflux for 1 h. After cooling, the precipitate obtained is drained,,washed with ethyl ether, dried and recrystallised in acetonitrile. A white powder is obtained.

Workup

  1. temperatureto reflux for 1 h
  2. temperatureAfter cooling
  3. customthe precipitate obtained
  4. customdried
  5. customrecrystallised in acetonitrile
  6. customA white powder is obtained

Sources & evidence

ORD record
ord-6e714b0aa8434d689d5abd929b323b13
Source dataset
uspto-grants-1994_03
Patent number
US05290790

Reaction notes

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