Potassium Carbonate → HCID 9947772, compound

HRID 486408Notes

Reaction equation

HRID 486408 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][CH:13]=[CH:12]2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:17]1[N:22]=[CH:21][CH:20]=[CH:19][N:18]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:18]1[CH:19]=[CH:20][CH:21]=[N:22][C:17]=1[N:4]1[CH2:3][CH2:2][N:1]([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][CH:13]=[CH:12]2)[CH2:6][CH2:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 744042-ChloropyrimidineHCID 20097022HCID 20097022, compound

Product 1

HCID 9947772HCID 9947772, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4.14 g (20 mmol) of 1-[4-(piperazinyl)-butyl)pyrrole, 2.29 g (20 mmol) of 2-chloropyrimidine and 4.1 g (30 mmol) of potassium carbonate in 60 ml of dimethylformamide is refluxed for 5 hours. The reaction mixture is evaporated under vacuum, chloroform is added and the mixture is washed with water, dried over sodium sulphate and evaporated under vacuum and 3.3 g of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}pyrrole are obtained in the form of a liquid.

Workup

  1. temperatureis refluxed for 5 hours
  2. customThe reaction mixture is evaporated under vacuum, chloroform
  3. additionis added
  4. washthe mixture is washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated under vacuum and 3.3 g of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}pyrrole
  7. customare obtained in the form of a liquid

Sources & evidence

ORD record
ord-be7009c213da41ddb6383baac1acda68
Source dataset
uspto-grants-1994_03
Patent number
US05292739

Reaction notes

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